Getting beyond things like developing a colour palette, or choosing brushes, is developing a concise layout that your viewers will understand.
I don’t normally start my design process on the iPad. I still prefer to push a pencil around on paper when I’m working up my initial concepts. I don’t want to fiddle around with colours, layers or brushes. I want to get my thoughts down as quickly as possible. When I use my sketchbook, the most I need to do is click my mechanical pencil for more lead, and turn a page.